The mucosal immune system for secretory IgA responses and mucosal vaccine development

Recombinant secretory IgA for immune intervention against mucosal pathogens.

Mucosal epithelia of the human body, including the lining of the digestive, respiratory and urogenital tracts, comprises a vast surface permanently exposed to attack by exogenous pathogens. Protection of mucosal surfaces against colonization and possible invasion by pathogenic microorganisms is provided by a combination of constitutive non-specific substances such as mucus, lysozyme, lactoferri...

The mucosal immune system: From dentistry to vaccine development

The oral cavity is the beginning of the aero-digestive tract, which is covered by mucosal epithelium continuously under the threat of invasion of pathogens, it is thus protected by the mucosal immune system. In the early phase of our scientific efforts for the demonstration of mucosal immune system, dental science was one of major driving forces due to their foreseeability to use oral immunity ...

Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses.

Secretory IgA (SIgA) is essential in protecting mucosal surfaces by ensuring immune exclusion. In addition, SIgA binds selectively to M cells in Peyer's patches (PP), resulting in transport across the epithelium and targeting of dendritic cells (DC) in the dome region. The immunological consequences of such an interaction are unknown. In this study, we find that oral delivery of SIgA comprising...

Immune Responses Systemic Properties Stimulating Mucosal and Secretory IgA Possesses Intrinsic Modulatory

Protection against Mucosal Infections by Secretory IgA

In the past decade, several model systems have been developed to study the details of the production of secretory IgA by the mucosal surface. Until recently, most attention in vaccine research has been directed toward establishing a vigorous systemic (predominantly IgG) humoral immune response to the infectious agent. With the recognition, however, that secretory IgA is overwhelmingly the predo...